Sempre più in basso: l’evoluzione nel tempo dei target per il colesterolo LDL nel diabete

The reduction of LDL cholesterol is associated with a reduction in cardiovascular morbidity and mortality, with no apparent threshold. The availability of new effective cholesterol-lowering drugs has induced Scientific Societies to recommend much lower targets for LDL cholesterol. Targets are differentiated on the basis of cardiovascular risk (the higher the risk, the lower the target). However, the determination of actual risk levels is problematic, particularly in the elderly. Clinical judgement is needed to adapt recommendations and identify proper targets in individual patients.